Acute Scrotal Ulcers in a 34-Year-Old Male With an Excellent Treatment Response: A Case Report

Juvenile gangrenous vasculitis of the scrotum (JGVS) is a rare disease, but it has a distinct presentation and a favourable response to treatment. In this clinical case, we present a male patient in his early 30s with tender scrotal ulcers, no history of sexually transmitted diseases or risk behaviours, and no previous systemic disease or immunosuppression. Studies revealed elevated inflammatory markers, but remarkably, all microbiologic studies were negative. The patient was diagnosed with JGVS and was treated with methylprednisolone 24 mg, tapered over two months, in combination with doxycycline 100 mg BID for one month, and topical clobetasol under occlusion, with complete healing in two months and no relapse. This case contributes to the existing knowledge of JGVS. Typically, patients are young, usually under 30 years old; however, this patient was slightly older. While exclusive scrotal involvement is common, this patient also exhibited smaller satellite ulcers on the adjacent thigh.

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Publication Details

Journal
Cureus
Published
2025-09-22
DOI
https://doi.org/10.7759/cureus.92952
Primary Topic
Autoimmune and Inflammatory Disorders
Type
article
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article

Acute Scrotal Ulcers in a 34-Year-Old Male With an Excellent Treatment Response: A Case Report

João N Soares, Maria Manuel Brites
Cureus
Autoimmune and Inflammatory Disorders
article

Acute Scrotal Ulcers in a 34-Year-Old Male With an Excellent Treatment Response: A Case Report

João N Soares, Maria Manuel Brites
article en

Abstract

Juvenile gangrenous vasculitis of the scrotum (JGVS) is a rare disease, but it has a distinct presentation and a favourable response to treatment. In this clinical case, we present a male patient in his early 30s with tender scrotal ulcers, no history of sexually transmitted diseases or risk behaviours, and no previous systemic disease or immunosuppression. Studies revealed elevated inflammatory markers, but remarkably, all microbiologic studies were negative. The patient was diagnosed with JGVS and was treated with methylprednisolone 24 mg, tapered over two months, in combination with doxycycline 100 mg BID for one month, and topical clobetasol under occlusion, with complete healing in two months and no relapse. This case contributes to the existing knowledge of JGVS. Typically, patients are young, usually under 30 years old; however, this patient was slightly older. While exclusive scrotal involvement is common, this patient also exhibited smaller satellite ulcers on the adjacent thigh.

CureusVol. 17(9)
University of Coimbra (PT)
Openalex Percentile: Top 65%
Autoimmune and Inflammatory Disorders
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