The diagnostic value of 18 F-FAPI-04 PET/CT in unresectable hepatocellular carcinoma: a head-to-head comparison with 18 F-FDG PET/CT
<sup>18</sup>F-FAPI-04 exhibits significant diagnostic advantages in uHCC patients, particularly in the detection of intrahepatic lesions, peritoneal metastases, and better contrast compared with <sup>18</sup>F-FDG. Among organ transplant recipients,<sup>18</sup>F-FDG may offer higher sensitivity than <sup>18</sup>F-FAPI-04 for intrahepatic lesion detection. <sup>18</sup>F-FDG outperforms <sup>18</sup>F-FAPI-04 in identifying PVTT. The rational selection of these two tracers may improve the accuracy of clinical staging.
Authors
- Xueying Ling (ORCID: https://orcid.org/0000-0001-9930-2006)
- Yong He (ORCID: https://orcid.org/0000-0002-9404-798X)
- Yongjin Tang
- Qijun Cai
- Hao Xu (ORCID: https://orcid.org/0000-0002-6199-3929)
- Mingrong Cao (ORCID: https://orcid.org/0000-0001-5672-2991)
- Kao‐Lang Liu (ORCID: https://orcid.org/0000-0003-4100-8909)
- Chengzhi Li (ORCID: https://orcid.org/0000-0001-9193-3014)
- Lu Wang (ORCID: https://orcid.org/0000-0003-2617-655X)
- Qiang Li (ORCID: https://orcid.org/0000-0002-4384-8226)
- Yulong Liu (ORCID: https://orcid.org/0000-0001-9891-8036)
- Jingjie Shang (ORCID: https://orcid.org/0000-0003-1038-0425)
- Yingxin Li (ORCID: https://orcid.org/0009-0004-9399-0708)
- Huanyu Gong (ORCID: https://orcid.org/0000-0002-5802-094X)
- Yong Cheng (ORCID: https://orcid.org/0000-0002-7462-7573)
- Lu Kuang
Institutions
- First Affiliated Hospital of Jinan University (CN)
Publication Details
- Journal
- European Journal of Nuclear Medicine and Molecular Imaging
- Published
- 2025-09-22
- DOI
- https://doi.org/10.1007/s00259-025-07548-w
- Citations
- 1
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 1.05