Peripheral neuromodulation in spasticity-plus syndrome: effects of pulsed radiofrequency on tonic-painful disorders in multiple sclerosis

This case illustrates the role of PRF in SPS management when pharmacological options are insufficient or poorly tolerated. PRF provides safe, repeatable peripheral neuromodulation without neuro-destructive effects, enabling multimodal, patient-centered care. Although based on a single case, these findings support the clinical value of the SPS construct and suggest PRF as a promising complementary strategy in MS-related disability.