Unveiling the neutrophil-Notch2-ISC axis: asiatic acid’s therapeutic strategy in infectious colitis

By revealing the neutrophil-Notch2-ISC axis as a pivotal regulator of mucosal repair, our findings show AA to be a dual-action therapeutic agent that synergizes immune containment and regenerative pathways. These findings highlight an aspect of <i>S.T</i> pathogenesis and underscore the potential of natural compounds to harmonize host defense and tissue regeneration, offering a transformative strategy for infectious colitis beyond conventional anti-inflammatory approaches.