Next-generation sequencing of mitochondrial DNA reveals pathogenic variants and protective haplogroup D4 in esophageal cancer
We found that the number of variations in multiple regions of the mitochondrial genome in the EC population was higher than that in the control group. Additionally, several potentially pathogenic variants were identified, and haplogroup D4 was suggested as a potentially protective haplogroup against the development of EC.
Authors
- Junbao Yang (ORCID: https://orcid.org/0000-0003-4969-937X)
- Xiucheng Jiang
- Bo Mu
- Shuhan Duan
- Bingbing Lv (ORCID: https://orcid.org/0000-0001-6829-6555)
- Jinyue Ma
- Cui Chen (ORCID: https://orcid.org/0000-0003-3863-0406)
- Tao Tang (ORCID: https://orcid.org/0000-0003-1431-1478)
- Mei Zhao
- Lihua Jia (ORCID: https://orcid.org/0000-0001-8764-5757)
- Yang Zhao (ORCID: https://orcid.org/0000-0002-6826-5430)
- Simeng Ji
- Lan Shi
- Jinlong Pang
Institutions
- North Sichuan Medical University (CN)
- Huzhou Vocational and Technical College (CN)
- Affiliated Hospital of North Sichuan Medical College (CN)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2025-09-22
- DOI
- https://doi.org/10.3389/fgene.2025.1643229
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00