Bone marrow adipose tissue expansion and bone loss in experimental chronic kidney disease is independent of altered bone marrow stromal cell lineage determination
In experimental CKD, BMAT expansion depends on CKD duration and does not appear to be driven by hypoleptinemia or hypercorticosteronemia, or by altered precursor cell differentiation during CKD onset.
Authors
- Katherine Staines (ORCID: https://orcid.org/0000-0002-8492-9778)
- Lucie E. Bourne (ORCID: https://orcid.org/0000-0003-3352-4946)
- Colin Farquharson (ORCID: https://orcid.org/0000-0002-4970-4039)
- Louise A. Stephen (ORCID: https://orcid.org/0000-0001-6795-0383)
- Soher Nagi Jayash (ORCID: https://orcid.org/0000-0001-5263-8557)
- William P. Cawthorn (ORCID: https://orcid.org/0000-0001-7832-5057)
- Worachet Promruk (ORCID: https://orcid.org/0009-0005-8268-1229)
- Aine Pears
Institutions
- Roslin Institute (GB)
- Chulabhorn Graduate Institute (TH)
- Chulabhorn Hospital (TH)
- University of Brighton (GB)
- University of Edinburgh (GB)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-09-22
- DOI
- https://doi.org/10.3389/fendo.2025.1666681
- Citations
- 2
- Primary Topic
- Bone and Joint Diseases
- Type
- article
- Field-Weighted Citation Impact
- 3.44
Funders
- Chulabhorn Royal Academy
- Directorate for Biological Sciences
- Medical Research Council
- Biotechnology and Biological Sciences Research Council