Genetic determinants of the complement and coagulation pathways in invasive meningococcal disease
The study demonstrates the value of a mechanistic pathway approach to describe the genetic landscape of infectious disease, particularly in understanding its course and outcome. Notably, we identify complement-mediated thrombotic microangiopathy as a key pathophysiologic mechanism involved, particularly in MD.
Authors
- Antonio Salas (ORCID: https://orcid.org/0000-0002-2336-702X)
- Meg Mashbat
- Suzanne T. Anderson (ORCID: https://orcid.org/0000-0003-1213-7787)
- David Santillo (ORCID: https://orcid.org/0009-0004-3966-4952)
- Luregn J. Schlapbach (ORCID: https://orcid.org/0000-0003-2281-2598)
- Karin van Leeuwen (ORCID: https://orcid.org/0000-0001-7783-655X)
- Marieke Emonts (ORCID: https://orcid.org/0000-0002-2822-3527)
- Vanessa Sancho‐Shimizu (ORCID: https://orcid.org/0000-0002-3519-0727)
- Werner Zenz (ORCID: https://orcid.org/0000-0002-6218-3143)
- Colin G. Fink (ORCID: https://orcid.org/0000-0002-8008-5870)
- Stéphane Paulus (ORCID: https://orcid.org/0000-0002-0703-9114)
- Evangelos Bellos (ORCID: https://orcid.org/0000-0002-3389-5715)
- Alberto López‐Lera (ORCID: https://orcid.org/0000-0002-9596-6910)
- Navin P. Boeddha (ORCID: https://orcid.org/0000-0001-9487-1218)
- Marcel van Deuren
- Victoria Wright (ORCID: https://orcid.org/0000-0001-7826-1516)
- Amédine Duret (ORCID: https://orcid.org/0000-0002-5810-2195)
- Federico Martinón‐Torres (ORCID: https://orcid.org/0000-0002-9023-581X)
- Jethro Herberg (ORCID: https://orcid.org/0000-0001-6941-6491)
- Stephanie Hodeib (ORCID: https://orcid.org/0000-0002-5978-6189)
- Enitan D. Carrol (ORCID: https://orcid.org/0000-0001-8357-7726)
- Margarita López‐Trascasa (ORCID: https://orcid.org/0000-0001-8594-282X)
- Taco Kuijpers
- Michael Levin (ORCID: https://orcid.org/0000-0003-2767-6919)
- Ronald de Groot (ORCID: https://orcid.org/0000-0001-5266-5002)
- Michiel van der Flier (ORCID: https://orcid.org/0000-0003-1296-0159)
- Gertjan J. Driessen
- Tom Sprong
- Fatou Secka
- Daniela Kohlfuerst
Institutions
- Radboud University Nijmegen (NL)
- University of Liverpool (GB)
- The University of Queensland (AU)
- Medical University of Graz (AT)
- Maastricht University Medical Centre (NL)
- Newcastle upon Tyne Hospitals NHS Foundation Trust (GB)
- Amsterdam UMC Location University of Amsterdam (NL)
- Radboud University Medical Center (NL)
- Sanquin (NL)
- Maastricht University (NL)
- University of Oxford (GB)
- MRC Clinical Trials Unit at UCL (GB)
- Hospital La Paz Institute for Health Research (ES)
- Radboud Institute for Molecular Life Sciences (NL)
- NIHR Imperial Biomedical Research Centre (GB)
- Centre for Biomedical Network Research on Rare Diseases (ES)
- Canisius-Wilhelmina Ziekenhuis (NL)
- MRC Unit the Gambia (GM)
- Newcastle upon Tyne Hospital (GB)
- Great North Children's Hospital (GB)
- Erasmus MC - Sophia Children’s Hospital (NL)
- Science Oxford (GB)
- Wilhelmina Children's Hospital (NL)
- University of Southampton (GB)
- University College London (GB)
- Imperial College London (GB)
- Universidad Autónoma de Madrid (ES)
- University of Amsterdam (NL)
- University of Warwick Science Park (GB)
Publication Details
- Journal
- Journal of Allergy and Clinical Immunology
- Published
- 2025-09-22
- DOI
- https://doi.org/10.1016/j.jaci.2025.09.011
- Primary Topic
- Bacterial Infections and Vaccines
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Micropathology