PSTPIP1 and pyrin, two key regulators of macrophage differentiation
PSTPIP1 and Pyrin are crucial factors in macrophage differentiation. Their deletion or mutation resulted in a hampered differentiation of macrophages resulting in strong morphological alterations and impacting phagocyte key functions as adhesion and migration. Impaired differentiation of macrophages may represent a significant factor in the pathophysiology of autoinflammatory diseases like FMF and PAPA.
Authors
- Lucas Lamparter (ORCID: https://orcid.org/0000-0003-3248-0056)
- Sophia Leußink (ORCID: https://orcid.org/0000-0002-1841-0003)
- Shalom J. Wind (ORCID: https://orcid.org/0000-0001-6524-7512)
- Judith Austermann (ORCID: https://orcid.org/0000-0001-6973-7260)
- Olesja Fehler (ORCID: https://orcid.org/0000-0001-6386-7080)
- Dominik Heider (ORCID: https://orcid.org/0000-0002-3108-8311)
- Monika Stoll (ORCID: https://orcid.org/0000-0002-2711-4281)
- Johannes Roth (ORCID: https://orcid.org/0000-0001-7035-8348)
- Milos Galic (ORCID: https://orcid.org/0000-0002-4493-2542)
- Shrey Gandhi (ORCID: https://orcid.org/0000-0002-1635-1062)
- Philipp Berger (ORCID: https://orcid.org/0000-0002-8147-1749)
- Selina K. Jorch (ORCID: https://orcid.org/0000-0002-6356-5012)
- Ralf Jürgens
- Carolin Walter (ORCID: https://orcid.org/0000-0002-5155-7728)
- Lisa Wilming
- Yevheniia Minchuk
Institutions
- University of Münster (DE)
- Augenstern (DE)
- University Hospital Münster (DE)
- RWTH Aachen University (DE)
Publication Details
- Journal
- European Journal of Cell Biology
- Published
- 2025-09-22
- DOI
- https://doi.org/10.1016/j.ejcb.2025.151518
- Citations
- 1
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.80