sgp130Fc alleviates cartilage degeneration and knee osteoarthritis by inhibiting IL-6 trans-signaling pathway
Targeted inhibition of IL-6 trans-signaling with sgp130Fc effectively mitigates cartilage degeneration and inflammation in OA, highlighting its potential as a novel disease-modifying therapeutic strategy for knee osteoarthritis.
Authors
- Jing Luo (ORCID: https://orcid.org/0000-0003-2702-120X)
- Lingjie Tan (ORCID: https://orcid.org/0000-0002-4794-8267)
- Chi Liang (ORCID: https://orcid.org/0000-0001-7902-7844)
- Chunrong He (ORCID: https://orcid.org/0000-0003-3836-4208)
- Jinshen He (ORCID: https://orcid.org/0000-0003-0277-3819)
- Xiao Ke (ORCID: https://orcid.org/0000-0002-2992-3752)
- Song Wu (ORCID: https://orcid.org/0000-0002-5304-3691)
Institutions
- Central South University (CN)
- Third Xiangya Hospital (CN)
- University of South China (CN)
Publication Details
- Journal
- Immunobiology
- Published
- 2025-09-22
- DOI
- https://doi.org/10.1016/j.imbio.2025.153122
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00