Changpu Yujin Tang mitigates tourette syndrome by enhancing mitophagy and suppressing NLRP3 inflammasome-mediated pyroptosis
CPYJT inhibits NLRP3 inflammasome activation and reduces pyroptosis by enhancing PINK1/Parkin-mediated mitophagy and attenuating ROS accumulation, which in turn ameliorates TS.
Authors
- Liwei Huang (ORCID: https://orcid.org/0000-0002-7590-144X)
- Manqi Lu
- Zhaoyu Shi (ORCID: https://orcid.org/0000-0002-8542-523X)
- Wei Dong Xing (ORCID: https://orcid.org/0000-0003-4098-4860)
- Jing Shang (ORCID: https://orcid.org/0000-0001-6713-292X)
- Shuang Huang (ORCID: https://orcid.org/0000-0002-9674-2249)
- Fu‐Shan Xue (ORCID: https://orcid.org/0000-0002-1028-6036)
- Kexin Sun (ORCID: https://orcid.org/0009-0008-8267-8195)
- Gao Lv (ORCID: https://orcid.org/0000-0003-3127-0348)
- Bing Jiang (ORCID: https://orcid.org/0000-0001-6594-4019)
- Mengxue Li (ORCID: https://orcid.org/0000-0003-1315-4706)
- Mingyang Sun
- Yuezhen He
Institutions
- Gansu University of Traditional Chinese Medicine (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Longhua Hospital Shanghai University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Immunobiology
- Published
- 2025-09-22
- DOI
- https://doi.org/10.1016/j.imbio.2025.153118
- Citations
- 1
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.81