Linear and conformational epitopes of vicilin-buried peptides as a model for improved nut allergy diagnostics
Cross-reactivity among VBPs most likely arises from monoclonal IgE binding to α-hairpin structures and their overlapping linear amino acid sequences. The combination of linear and conformational IgE binding patterns enabled us to differentiate between the WNA, PNA, and PWA groups in this study and may assist us in using AH1LS and JR2LS to distinguish PN and WN allergies in the future.
Authors
- Stephen C. Dreskin (ORCID: https://orcid.org/0000-0003-3548-5530)
- Alexander C. Y. Foo (ORCID: https://orcid.org/0000-0002-4331-2085)
- Jacqueline B. Nesbit (ORCID: https://orcid.org/0000-0002-9326-7286)
- Scott A. Smith (ORCID: https://orcid.org/0000-0002-5519-8662)
- Stephen A. Y. Gipson (ORCID: https://orcid.org/0000-0001-5173-3309)
- Michael D. Kulis (ORCID: https://orcid.org/0000-0001-8092-7444)
- Ian M. Rambo (ORCID: https://orcid.org/0000-0002-2736-2832)
- S. Shahzad Mustafa (ORCID: https://orcid.org/0000-0001-9691-7590)
- Dieu Doan (ORCID: https://orcid.org/0000-0002-0781-6358)
- Soheila J. Maleki (ORCID: https://orcid.org/0000-0002-6056-9958)
- Adam R. Rivers (ORCID: https://orcid.org/0000-0002-3703-834X)
- Stacie M. Jones (ORCID: https://orcid.org/0000-0003-3491-4815)
- Lauren T. Swientoniewski (ORCID: https://orcid.org/0000-0003-1263-6404)
- Geoffrey A. Mueller (ORCID: https://orcid.org/0000-0001-8361-5323)
- Hsiaopo Cheng
Institutions
- Arkansas Children's Hospital (US)
- United States Department of Agriculture (US)
- National Institute of Environmental Health Sciences (US)
- Unity Health System (US)
- Applied Physical Sciences (United States) (US)
- University of Rochester (US)
- Delgado Community College (US)
- Vanderbilt University Medical Center (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Frontiers in Allergy
- Published
- 2025-09-22
- DOI
- https://doi.org/10.3389/falgy.2025.1648262
- Primary Topic
- Food Allergy and Anaphylaxis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Agriculture
- Nestlé Health Science
- Aimmune Therapeutics
- National Institutes of Health
- National Institute of Food and Agriculture
- Agricultural Research Service