Multiomics profiling identifies the poor prognostic role of a tumor cluster with GNA15 overexpression in triple-negative breast cancer
Our study comprehensively delineated TNBC tumor cell heterogeneity and established the critical role of <i>GNA15</i> in TNBC progression. These findings enhance the understanding of TNBC heterogeneity and provide a theoretical foundation for TNBC treatment.
Authors
- Yao Tian (ORCID: https://orcid.org/0000-0003-4680-6889)
- Chenglu Lu (ORCID: https://orcid.org/0000-0002-5198-0016)
- Yu Cao (ORCID: https://orcid.org/0000-0003-3471-1719)
- Guixin Wang (ORCID: https://orcid.org/0000-0002-4850-9207)
- Yingxi Li (ORCID: https://orcid.org/0000-0002-3848-1992)
- Xuejun Wang (ORCID: https://orcid.org/0000-0001-9267-1343)
- Ziyi Chen (ORCID: https://orcid.org/0009-0000-4488-2322)
- Yue Yu (ORCID: https://orcid.org/0000-0003-2053-9866)
- Shuo Wang (ORCID: https://orcid.org/0000-0002-7443-7999)
- Zhaohui Chen (ORCID: https://orcid.org/0000-0003-0688-9798)
- Junming Cao (ORCID: https://orcid.org/0009-0004-7581-2959)
Institutions
- Ningbo University (CN)
- Zunyi Medical University (CN)
- Tianjin Medical University General Hospital (CN)
- Tianjin Medical University Cancer Institute and Hospital (CN)
- Tangshan People's Hospital (CN)
- Ningbo Medical Center Lihuili Hospital (CN)
- Ningbo College of Health Sciences (CN)
- Ningbo University Affiliated Hospital (CN)
- Affiliated Hospital of Zunyi Medical College (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-22
- DOI
- https://doi.org/10.3389/fimmu.2025.1659183
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00