TP53 expression in PCAT in coronary artery disease combined with type 2 diabetes mellitus and its correlation with CCTA radiomic features: novel imaging biomarkers

<i>TP53</i> expression was significantly elevated in the PCAT of patients with CAD combined with T2DM, suggesting that this molecule plays a role in the development of this disease. Four first-order features and 10 texture features in the PCAT radiomic features were associated with abnormal <i>TP53</i> expression. The association of radiomic features with <i>TP53</i> suggests that CCTA-based radiomic features can be used to predict abnormalities in differential gene expression, thus providing a new way to noninvasively predict CAD combined with T2DM.