Zuojin capsule improves T cell exhaustion and tumor immune microenvironment of hepatocellular carcinoma through the mTOR-eIF4E/p70S6K-CDK1 pathway
ZJC exerts dual anti-tumor effects by inhibiting the mTOR-eIF4E/p70S6K-CDK1 pathway and remodeling the immunosuppressive microenvironment of HCC.
Authors
- Jiali Deng (ORCID: https://orcid.org/0000-0001-9076-858X)
- Xiaoyu Hu (ORCID: https://orcid.org/0000-0001-8129-7085)
- Liyuan Hao (ORCID: https://orcid.org/0000-0001-9429-5134)
- Shenghao Li (ORCID: https://orcid.org/0000-0002-8968-7333)
Institutions
- Hebei Medical University (CN)
- Fourth Hospital of Hebei Medical University (CN)
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-22
- DOI
- https://doi.org/10.3389/fimmu.2025.1617604
- Primary Topic
- Cancer Mechanisms and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00