Extracellular vesicles of patients with acute-on-chronic liver failure induce mitochondrial dysfunction in T cells
Liver cirrhosis is associated with distinct changes in circulating EVs. In ACLF, EVs are less differentiated and induce mitochondrial dysfunction, decreased T cell viability and changes in the composition of T cell populations.
Authors
- Sabrina Guckenbiehl
- Bernd Walkenfort (ORCID: https://orcid.org/0000-0002-7789-3340)
- Markus Kaiser (ORCID: https://orcid.org/0000-0002-6540-8520)
- Alina Bauschen
- Helena Stadler
- Farnusch Kaschani (ORCID: https://orcid.org/0000-0001-6572-3232)
- Christian M. Lange (ORCID: https://orcid.org/0000-0001-9983-5136)
- Heiner Wedemeyer
- Mona‐May Langer
Institutions
- LMU Klinikum (DE)
- Medizinische Hochschule Hannover (DE)
- Essen University Hospital (DE)
- University of Duisburg-Essen (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-22
- DOI
- https://doi.org/10.3389/fimmu.2025.1656692
- Citations
- 1
- Primary Topic
- Liver Disease and Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 1.32
Funders
- Deutsche Forschungsgemeinschaft
- Friedrich-Baur-Stiftung