Tissue-resident memory CD8+T cells might enhance HBV DNA clearance in CHB patients with MASLD complication and normal ALT via the CCL-CCR pathways
CD8+ Trm-CD69 T cells may be activated by Monocyte-THBS1 cells, thereby stimulating the immune system via the CCL-CCR signaling axis. This activation facilitates the recruitment of immune cells and enhances the clearance of hepatitis B virus (HBV).
Authors
- Ruicong Chen (ORCID: https://orcid.org/0000-0002-7932-1610)
- Yu-Qun Wang
- Mingqin Lu (ORCID: https://orcid.org/0000-0002-8331-5862)
- Wen-Xuan Shang
- Ji Lin (ORCID: https://orcid.org/0000-0001-7206-6111)
- Chuan Cai
- Ke Xu (ORCID: https://orcid.org/0000-0002-2796-6177)
- Lei Zhang (ORCID: https://orcid.org/0009-0008-9783-092X)
- Yajie Wang (ORCID: https://orcid.org/0000-0002-3285-2537)
- Chen Huang (ORCID: https://orcid.org/0000-0002-2407-9716)
- Huifang Zhang (ORCID: https://orcid.org/0009-0001-4327-3266)
- Lü Chen (ORCID: https://orcid.org/0000-0001-5527-7881)
- Yijing Cai
- Bangguo Zhou
- Xiuli Lin
- Si-Jie Zheng
- Chen Chen (ORCID: https://orcid.org/0000-0001-7846-0371)
Institutions
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- First Affiliated Hospital Zhejiang University (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-09-22
- DOI
- https://doi.org/10.3389/fcimb.2025.1653566
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wenzhou Medical University
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Science and Technology Plan Project of Wenzhou, China
- Natural Science Foundation of Zhejiang Province