Clinical predictors and concomitant antiseizure medications effects on seizure control in relation to plasma cenobamate concentration: a multicenter retrospective study
These findings suggest that CNB may achieve clinically meaningful seizure control at relatively low doses, with variability in plasma concentrations largely influenced by concomitant medications and, to a lesser extent, by individual characteristics. Despite the limited sample size, our results highlight the value of therapeutic drug monitoring and individualized titration to optimize CNB therapy in drug-resistant focal epilepsy.
Authors
- Albino Coglianese (ORCID: https://orcid.org/0000-0002-2724-8212)
- Grazia Maria Giovanna Pastorino (ORCID: https://orcid.org/0000-0003-0404-5495)
- Rosaria Renna (ORCID: https://orcid.org/0000-0002-5913-3153)
- Laura Canafoglia (ORCID: https://orcid.org/0000-0002-5385-761X)
- Mariana Fernandes (ORCID: https://orcid.org/0000-0002-7005-2805)
- Antonio Gambardella (ORCID: https://orcid.org/0000-0001-7384-3074)
- Ilaria Sammarra (ORCID: https://orcid.org/0000-0003-4136-9245)
- Antonio Balsamo (ORCID: https://orcid.org/0000-0002-9313-263X)
- Viviana Izzo (ORCID: https://orcid.org/0000-0001-6066-7569)
- Giovanni Assenza (ORCID: https://orcid.org/0000-0003-3129-1982)
- Bruno Charlier (ORCID: https://orcid.org/0000-0002-5076-3220)
- Francesca Felicia Operto (ORCID: https://orcid.org/0000-0002-2444-8761)
- Carlo Di Bonaventura (ORCID: https://orcid.org/0000-0003-1890-5409)
- Mario Tombini (ORCID: https://orcid.org/0000-0002-0328-7815)
- Claudio Liguori (ORCID: https://orcid.org/0000-0003-2845-1332)
- Matteo Antonucci
- Marianna Pezzella (ORCID: https://orcid.org/0009-0000-5594-2597)
- Emanuele Cerulli Irelli
Institutions
- University of Rome Tor Vergata (IT)
- University of Salerno (IT)
- Università Campus Bio-Medico (IT)
- University of Sannio (IT)
- Magna Graecia University (IT)
- Ospedale Antonio Cardarelli (IT)
- Ospedali Riuniti San Giovanni di Dio e Ruggi d'Aragona (IT)
- Campus Bio Medico University Hospital (IT)
- Fondazione IRCCS Istituto Neurologico Carlo Besta (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-09-22
- DOI
- https://doi.org/10.3389/fphar.2025.1668382
- Citations
- 2
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.94