Population pharmacokinetics modelling to predict DDI from zopiclone on clozapine in schizophrenia patients
When zopiclone was taken concurrently, clozapine dosage need to be reduced. Based on this, schizophrenia patients individualized dosage adjustment was recommended.
Authors
- Xue Tian (ORCID: https://orcid.org/0000-0001-6162-2856)
- Su‐Mei He
- Ye Li (ORCID: https://orcid.org/0000-0002-1624-8831)
- Xiaohong Chen (ORCID: https://orcid.org/0000-0002-9797-8384)
- Jie Wang (ORCID: https://orcid.org/0000-0002-7351-8332)
- Dongdong Wang (ORCID: https://orcid.org/0000-0003-2737-6748)
- Cun Zhang (ORCID: https://orcid.org/0000-0002-9381-9730)
- Yue Zhang (ORCID: https://orcid.org/0000-0002-8463-0223)
- Huanhuan Han
Institutions
- Xuzhou Medical College (CN)
- Lianyungang Oriental Hospital (CN)
- Suzhou Municipal Hospital (CN)
Publication Details
- Journal
- Frontiers in Psychiatry
- Published
- 2025-09-22
- DOI
- https://doi.org/10.3389/fpsyt.2025.1664678
- Primary Topic
- Schizophrenia research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jiangsu Commission of Health
- Government of Jiangsu Province
- Xuzhou Medical University