Metagenomic insights into respiratory viral signatures in lower respiratory tract infections with and without respiratory failure
The overall composition and diversity of the respiratory microbiome were insufficient to distinguish LRTI from non-LRTI conditions. However, within the LRTI cohort, patients with RF exhibited distinct viral taxonomic profiles compared to non-RF individuals. Additionally, several viral taxa were correlated with host clinical indicators irrespective of clinical subgroup. These findings highlight virome compositional differences associated with RF within LRTI patients, but do not imply causal effects, and warrant further investigation.
Authors
- Jinying Gao (ORCID: https://orcid.org/0000-0001-7805-7865)
- Ning Hua Zhu (ORCID: https://orcid.org/0000-0002-1824-8317)
- Xiaohan Guo
- Qingtian Guan (ORCID: https://orcid.org/0000-0001-5903-1774)
- Ruihong Wu (ORCID: https://orcid.org/0000-0001-7585-0059)
- Dong Sun
- Shanshan Jia (ORCID: https://orcid.org/0000-0003-0925-5918)
Institutions
- Jilin University (CN)
- First Hospital of Jilin University (CN)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-09-22
- DOI
- https://doi.org/10.3389/fcimb.2025.1637352
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jilin University
- First Hospital of Jilin University