Cross-disease biomarker identification reveals shared diagnostic biomarkers for IVDD and NAFLD via bulk and single-cell RNA sequencing
This study identifies ME1, HAS2, and ADRB2 as pivotal shared biomarkers for IVDD and NAFLD, providing new insights into their molecular interconnection. The findings enhance our understanding of the comorbid mechanisms and highlight the potential of exercise as a therapeutic strategy for both conditions. These results pave the way for further mechanistic and clinical research into common pathways and integrated treatment approaches.
Authors
- Linhui Han
- Ximing Xu (ORCID: https://orcid.org/0000-0003-1654-3846)
- Jianshe Wei (ORCID: https://orcid.org/0000-0002-3560-3392)
- Kaiqiang Sun (ORCID: https://orcid.org/0000-0002-0272-8383)
- Lina Liu (ORCID: https://orcid.org/0000-0002-1362-4782)
- Yan Chen (ORCID: https://orcid.org/0000-0001-5325-1151)
- Wenbo Lin (ORCID: https://orcid.org/0000-0003-4329-6545)
- Chenglong Ji (ORCID: https://orcid.org/0000-0002-3400-1330)
Institutions
- Second Military Medical University (CN)
- Shanghai Changzheng Hospital (CN)
- PLA Navy General Hospital (CN)
- Xinxiang Central Hospital (CN)
- Henan Medical University (CN)
Publication Details
- Journal
- Frontiers in Molecular Neuroscience
- Published
- 2025-09-22
- DOI
- https://doi.org/10.3389/fnmol.2025.1639705
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China