Dual-edged mechanisms of α-tomatine in hepatocellular carcinoma by suppression of Wnt/β-catenin signaling versus RelB-Driven resistance in tumor therapy
This plant-derived alkaloid exerts anti-HCC effects through Wnt pathway modulation, while compensatory RelB activation constrains therapeutic outcomes. Strategic RelB co-targeting establishes a dual pathway phytotherapy paradigm, synergistically merging botanical pharmacodynamics with precision oncology.
Authors
- Tianzhen Wang (ORCID: https://orcid.org/0000-0002-7525-8466)
- Chenyue Xu (ORCID: https://orcid.org/0000-0002-8484-3181)
- Bianhong Zhang (ORCID: https://orcid.org/0000-0002-8669-2495)
- Yanling Yuan
Institutions
- East China Normal University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-09-22
- DOI
- https://doi.org/10.3389/fphar.2025.1616975
- Primary Topic
- Phytochemicals and Antioxidant Activities
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality