Cardiac-induced brain tissue motion in Chiari Malformation type 1 subjects and its relationship to symptomatology, morphometrics, and surgical outcomes
While displacement increases with anatomical crowding and normalizes after surgery, it does not predict clinical symptoms or surgical outcomes. Future work should combine multiple biomechanical markers and detailed symptom scales in an effort to develop a multidimensional biomarker for guiding treatment and assessing recovery in CMI.
Authors
- Christopher Maclellan
- Seyed Amir Ebrahimzadeh (ORCID: https://orcid.org/0000-0003-4927-8444)
- John N. Oshinski (ORCID: https://orcid.org/0000-0003-0043-7870)
- Rouzbeh Amini (ORCID: https://orcid.org/0000-0003-3632-6195)
- Rafeeque Bhadelia (ORCID: https://orcid.org/0000-0003-1952-9732)
- Francis Loth (ORCID: https://orcid.org/0000-0001-7651-521X)
- Mahsa Karamzadeh (ORCID: https://orcid.org/0009-0001-1708-9158)
- Mohamad Motaz Al Samman
Institutions
- Northeastern University (US)
- Beth Israel Deaconess Medical Center (US)
- Emory University (US)
Publication Details
- Journal
- Magnetic Resonance Imaging
- Published
- 2025-09-22
- DOI
- https://doi.org/10.1016/j.mri.2025.110530
- Primary Topic
- Spinal Dysraphism and Malformations
- Type
- article
- Field-Weighted Citation Impact
- 0.00