Palladium-catalyzed Heck/polyfluoroarylation of alkene-tethered carbamoyl chlorides with polyfluoroarenes
We developed a Pd-catalyzed Heck/polyfluoroarylation cascade to synthesize polyfluoroarylated oxindoles with all-carbon quaternary centers from alkene-tethered carbamoyl chlorides. The reaction was extended to a three-component one-pot protocol using amines, BTC, and polyfluoroarenes, with preliminary asymmetric results achieved.
Authors
- Xinyu Hu (ORCID: https://orcid.org/0000-0002-5956-7269)
- Chunjie Ni (ORCID: https://orcid.org/0000-0003-1479-5484)
- Yanping Zhu (ORCID: https://orcid.org/0000-0003-1666-1850)
- Bolin Zhu (ORCID: https://orcid.org/0000-0002-6846-566X)
- Xiao-Xu Zhang
- Chen Chen (ORCID: https://orcid.org/0000-0002-5388-9611)
- Ziyi Wang (ORCID: https://orcid.org/0009-0005-3334-3266)
Institutions
- Tianjin Normal University (CN)
- Tianjin Chengjian University (CN)
- Yantai University (CN)
- Yancheng Teachers University (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc04604a
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00