Unleashing the immune modulatory potential of Leishmania amazonensis-derived extracellular vesicles in American cutaneous leishmaniasis
Thus, this study's findings suggest that although <i>L. amazonensis</i>-derived EVs can trigger MΦs activation, favoring a pro-inflammatory immune response, they also have the potential to ensure parasite survival while limiting host pathogenesis. This can be advantageous for parasite transmission and essential for completing the parasite life cycle.
Authors
- Rodrigo Pedro Soares (ORCID: https://orcid.org/0000-0002-7966-3629)
- Armanda Rodrigues (ORCID: https://orcid.org/0000-0003-4261-3879)
- Munira Muhammad Abdel Baqui (ORCID: https://orcid.org/0000-0002-7945-2899)
- Joana Palma-Marques (ORCID: https://orcid.org/0000-0001-6639-1495)
- Ana Cláudia Torrecilhas (ORCID: https://orcid.org/0000-0001-5724-2199)
- Hélida Monteiro de Andrade (ORCID: https://orcid.org/0000-0003-2823-4530)
- Juliana Inês Weber (ORCID: https://orcid.org/0000-0002-6504-4384)
- Ana Valério-Bolas (ORCID: https://orcid.org/0000-0002-0273-4353)
- Raul Alexander Gonzáles-Córdova (ORCID: https://orcid.org/0000-0003-4549-1643)
- Gabriela Santos‐Gomes (ORCID: https://orcid.org/0000-0001-9264-3887)
- Isabel Pereira da Fonseca (ORCID: https://orcid.org/0000-0002-6632-1224)
- Graça Alexandre‐Pires (ORCID: https://orcid.org/0000-0002-9462-4679)
- Micheli Ferla
- Bruna Eugênia de Freitas
Institutions
- Universidade Federal de Minas Gerais (BR)
- University of Lisbon (PT)
- Universidade de São Paulo (BR)
- Instituto de Medicina Tropical (PY)
- Instituto de Ciências Farmacêuticas (BR)
- Centre for Research in Anthropology (PT)
- Association for the Development of Douro Viticulture (PT)
- Clinics Hospital of Ribeirão Preto (BR)
- Fundação Oswaldo Cruz (BR)
- Universidade Nova de Lisboa (PT)
Publication Details
- Journal
- Frontiers in Molecular Biosciences
- Published
- 2025-09-22
- DOI
- https://doi.org/10.3389/fmolb.2025.1593363
- Primary Topic
- Research on Leishmaniasis Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00