Deep Phenotyping of Heart Failure with Preserved Ejection Fraction Through Multi-Omics Integration
We identified HFpEF phenotypes at an early stage, often several years before the onset of clinical symptoms, when the disease trajectory may still be amenable to modification. The molecular characterization provides novel insights into the underlying disease complexity and enables more refined risk stratification.
Authors
- Marcus Kelm (ORCID: https://orcid.org/0000-0003-4971-0452)
- Michael Gotthardt (ORCID: https://orcid.org/0000-0003-1788-3172)
- Nicola Wilck (ORCID: https://orcid.org/0000-0003-3189-5364)
- Frank Edelmann (ORCID: https://orcid.org/0000-0003-4401-5936)
- Philipp Mertins (ORCID: https://orcid.org/0000-0002-2245-528X)
- Titus Küehne (ORCID: https://orcid.org/0000-0003-1631-4824)
- Nina Jovanović (ORCID: https://orcid.org/0000-0001-6300-9705)
- Sofia Kirke Forslund (ORCID: https://orcid.org/0000-0003-4285-6993)
- Benjamin Wild (ORCID: https://orcid.org/0000-0002-7492-8448)
- Roland Eils (ORCID: https://orcid.org/0000-0002-0034-4036)
- Gabriele G. Schiattarella (ORCID: https://orcid.org/0000-0002-7582-7171)
- Ulrike Löber (ORCID: https://orcid.org/0000-0001-7468-9531)
- Holger Gerhardt (ORCID: https://orcid.org/0000-0002-3030-0384)
- Dominik N. Müller (ORCID: https://orcid.org/0000-0003-3650-5644)
- Jakob Versnjak
- Pauline Fahjen (ORCID: https://orcid.org/0000-0002-5015-0643)
Institutions
- Helmholtz Association of German Research Centres (DE)
- Max Delbrück Center (DE)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Humboldt-Universität zu Berlin (DE)
- Deutsches Herzzentrum der Charité (DE)
- German Centre for Cardiovascular Research (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- University College London (GB)
- Freie Universität Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- European Journal of Heart Failure
- Published
- 2025-09-22
- DOI
- https://doi.org/10.1002/ejhf.70041
- Citations
- 5
- Primary Topic
- Heart Failure Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 6.94