Effect of Glucagon-Like Peptide-1 Receptor Agonists on Heart Failure Outcomes and Cardiovascular Death Across Varying Cardiovascular-Kidney-Metabolic Comorbidity
Glucagon-like peptide-1 receptor agonists reduce HFH and CV death across CKM conditions, with generally consistent effects in varying combinations of these diseases. The potential exception is among patients with HFrEF, where a reduction in risk of CV death, but a numeric increase in HFH, was observed. Definitive CV outcome trials are needed to definitively determine effects of GLP-1RAs in patients with established HFrEF.
Authors
- Tariq Jamal Siddiqi
- Michael D. Shapiro
- Javed Butler (ORCID: https://orcid.org/0000-0001-7683-4720)
- Ambarish Pandey (ORCID: https://orcid.org/0000-0001-9651-3836)
- James Louis Januzzi (ORCID: https://orcid.org/0000-0002-8338-1798)
- Aasim Afzal (ORCID: https://orcid.org/0000-0003-1557-8190)
- Harriette G.C. Van Spall (ORCID: https://orcid.org/0000-0002-8370-4569)
- Gregg C. Fonarow (ORCID: https://orcid.org/0000-0002-3192-8093)
- Shoaib Waqas (ORCID: https://orcid.org/0000-0002-5592-3596)
- Muhammad Shahzeb Khan (ORCID: https://orcid.org/0000-0002-9089-8330)
- Stephen J. Greene
Institutions
- Harvard University (US)
- Duke University (US)
- Baylor College of Medicine (US)
- Temple College (US)
- Ronald Reagan UCLA Medical Center (US)
- Baylor University Medical Center (US)
- Jackson Memorial Hospital (US)
- University of Mississippi Medical Center (US)
- Dow University of Health Sciences (PK)
- Massachusetts General Hospital (US)
- Clinical Research Institute (US)
- Baim Institute for Clinical Research (US)
- Heart Hospital Baylor Plano (US)
- Baylor Scott & White Health (US)
- Wake Forest University (US)
- The University of Texas Southwestern Medical Center (US)
- McMaster University (CA)
Publication Details
- Journal
- European Journal of Heart Failure
- Published
- 2025-09-22
- DOI
- https://doi.org/10.1002/ejhf.70048
- Citations
- 7
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 9.06