HORMONAL IMBALANCES AND THEIR ASSOCIATION TO PCOS AND UTERINE FIBROIDS IN YOUNG PAKISTANI WOMEN

Objective: This study aimed to investigate the relationship between hormonal imbalances, Polycystic Ovary Syndrome (PCOS), and uterine fibroids in young Pakistani women aged 18 to 35 years. Methods: A cross-sectional observational study was conducted with 330 female patients presenting symptoms of hormonal imbalances. Data collection involved structured interviews, standardized questionnaires, clinical assessments, hormonal profiling, ultrasound imaging, and Body Mass Index (BMI) calculation. Descriptive statistics, correlation, and multiple logistic regression analyses were used to identify the association between hormonal imbalances and reproductive conditions. Results: Among the 330 participants, 57.6% were diagnosed with PCOS and 27.3% with uterine fibroids. PCOS patients showed elevated androgen levels (60 ng/dL) and insulin resistance (65%), while fibroid patients exhibited high estrogen levels (350 pg/mL) and low progesterone levels (4 ng/mL). Metabolic disturbances, including insulin resistance and abnormal lipid profiles, were more prevalent in the PCOS group. Additionally, psychological impacts such as depression and anxiety were reported by 50% of PCOS patients and 35% of fibroid patients. Conclusion: Hormonal imbalances, particularly elevated androgens and estrogen, significantly contribute to the development of PCOS and uterine fibroids in young Pakistani women. Early detection and comprehensive management are essential to prevent long-term reproductive and metabolic complications.