DNA cross-link repair deficiency enhances human cell sensitivity to colibactin-induced genotoxicity
These findings suggest that colibactin, produced by clb⁺ E. coli, can play a role in the formation of ICLs, thereby contributing significantly to the induction of chromosomal aberrations and the inhibition of human cell proliferation.
Authors
- Michihiro Mutoh (ORCID: https://orcid.org/0000-0003-2054-7655)
- Michio Sato (ORCID: https://orcid.org/0000-0002-6026-8426)
- Noriyuki Miyoshi (ORCID: https://orcid.org/0000-0002-4233-4282)
- Hideki Ishikawa (ORCID: https://orcid.org/0000-0001-5980-698X)
- Kenji Watanabe (ORCID: https://orcid.org/0000-0002-0463-4831)
- Yuuta Hisatomi
- Keiji Wakabayashi (ORCID: https://orcid.org/0000-0003-4746-4702)
- Takashi Yagi (ORCID: https://orcid.org/0000-0002-5476-8424)
- Masanobu Kawanishi
- Yoshimitsu Oda
- Osamu Tsubohira
- Ai Ueshima
Institutions
- University of Shizuoka (JP)
- Osaka Prefecture University (JP)
- Kyoto Prefectural University of Medicine (JP)
Publication Details
- Journal
- Genes and Environment
- Published
- 2025-09-22
- DOI
- https://doi.org/10.1186/s41021-025-00339-7
- Citations
- 1
- Primary Topic
- DNA Repair Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Japan Agency for Medical Research and Development
- Japan Society for the Promotion of Science