Computed Tomography and Magnetic Resonance Imaging Findings in Early Glioblastoma (e-GBM): Spotting the Wolf in Sheep’s Clothing

e-GBM should be considered in patients presenting with neurological symptoms, in particular seizures, when T2WI or FLAIR signal abnormalities in a cortical or subcortical location are seen with associated restricted diffusion. Hyperdensity on non-contrast CT imaging congruent with areas of signal change on MRI should also prompt clinicians to consider e-GBM as a differential diagnosis.

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Publication Details

Journal
Cureus
Published
2025-09-22
DOI
https://doi.org/10.7759/cureus.92895
Primary Topic
Glioma Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Computed Tomography and Magnetic Resonance Imaging Findings in Early Glioblastoma (e-GBM): Spotting the Wolf in Sheep’s Clothing

Pranav Sharma, Jennie Roberts, Rosalind L. Jeffree, Sarah Li et al.
Cureus
Glioma Diagnosis and Treatment
article

Computed Tomography and Magnetic Resonance Imaging Findings in Early Glioblastoma (e-GBM): Spotting the Wolf in Sheep’s Clothing

Pranav Sharma, Jennie Roberts, Rosalind L. Jeffree, Sarah Li, Aiyapa Ajjikuttira, Mohammadreza Haghighatpanah
article en

Abstract

e-GBM should be considered in patients presenting with neurological symptoms, in particular seizures, when T2WI or FLAIR signal abnormalities in a cortical or subcortical location are seen with associated restricted diffusion. Hyperdensity on non-contrast CT imaging congruent with areas of signal change on MRI should also prompt clinicians to consider e-GBM as a differential diagnosis.

CureusVol. 17(9)
Royal Brisbane and Women's Hospital (AU)
Openalex Percentile: Top 65%
Glioma Diagnosis and Treatment
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