A sodium ion-selective photosensitizer: dibrominated F-BODIPY as a fluorescence imaging and therapeutic agent
Herein, we report that the production of singlet oxygen (<sup>1</sup>O<sub>2</sub>) is exclusively regulated by sodium ions in aqueous solution by the use of a Na<sup>+</sup>-selective photosensitizer (PS), a 2,6-dibrominated F-BODIPY dye equipped with benzo-15-crown-5. The PS showed an enhanced fluorescence quantum yield (<i>Φ</i><sub>f</sub>) and an enhanced singlet oxygen quantum yield (<i>Φ</i><sub>Δ</sub>) in the presence of Na<sup>+</sup>. A detailed theoretical study uncovered the underlying photophysical pathways which are responsible for both functional characteristics of the PS, therapeutic and Na<sup>+</sup> imaging properties.
Authors
- Nora Kulak (ORCID: https://orcid.org/0000-0002-8347-4046)
- Vinja Hergl
- Julian Heinrich (ORCID: https://orcid.org/0009-0009-9575-3163)
- Eric Sperlich (ORCID: https://orcid.org/0000-0002-3118-9518)
- Alexandra Kelling
- Tobias Sprenger
- Nicolas Jahn (ORCID: https://orcid.org/0009-0000-7578-5154)
- Thomas Schwarze (ORCID: https://orcid.org/0000-0002-1351-0371)
- Tillmann Klamroth (ORCID: https://orcid.org/0000-0001-5555-5490)
- Mazen Al Akrami
Institutions
- University of Potsdam (DE)
Publication Details
- Journal
- Physical Chemistry Chemical Physics
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cp03172a
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft