Dual-phase exenatide delivery system: PLGA nanoparticles embedded in thermosensitive PLGA-PEG-PLGA hydrogel for sustained glycemic control
This system overcomes technical bottlenecks of conventional PLGA carriers and single-phase gels through modulation of release kinetics, offering a biocompatible and clinically translatable solution for long-acting polypeptide delivery.
Authors
- Tian Yin (ORCID: https://orcid.org/0000-0001-7039-0479)
- Jingxin Gou (ORCID: https://orcid.org/0000-0002-7388-2716)
- Nan Dong (ORCID: https://orcid.org/0000-0003-0432-7337)
- Yu Zhang (ORCID: https://orcid.org/0000-0003-0978-2363)
- Haibing He
- Xing Tang (ORCID: https://orcid.org/0000-0002-7051-9823)
- Shu Pan (ORCID: https://orcid.org/0000-0002-3783-7686)
- Haoyang Yuan (ORCID: https://orcid.org/0000-0002-4059-3184)
- Yanjiao Wang
Institutions
- Shenyang Pharmaceutical University (CN)
Publication Details
- Journal
- Expert Opinion on Drug Delivery
- Published
- 2025-09-22
- DOI
- https://doi.org/10.1080/17425247.2025.2564870
- Citations
- 2
- Primary Topic
- Advanced Drug Delivery Systems
- Type
- article
- Field-Weighted Citation Impact
- 1.58