A Preliminary Study of Heart and Brain Autoreactivity After Group A Streptococcal Carbohydrate Antigen Immunization in Rabbits

There is current interest in the group A streptococcal carbohydrate as a vaccine antigen, and previous studies have suggested that it may induce host tissue cross-reactive autoantibodies which react with heart and brain autoantigens and which are present in streptococcal sequelae, including rheumatic heart disease, Sydenham chorea, and pediatric autoimmune neuropsychiatric disorder associated with streptococci (PANDAS) [...]