Clinical and Molecular Characteristics of 100 Atypical Teratoid Rhabdoid Tumor Patients from Low- and Middle-Income Countries

In this cohort, no significant survival differences were observed among the methylation subgroups. The higher treatment-related mortality in our cohort compared to the original protocol's toxic-related deaths suggested that intensive and lengthy chemotherapy regimens may need modification for our population. The need for a short intensified approach, including a limited induction cycle followed by an intensified high-dose consolidation therapy, may be more appropriate for our patients with low socioeconomic status to avoid a repeated and prolonged course of protracted neutropenia.

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Publication Details

Journal
Cancers
Published
2025-09-20
DOI
https://doi.org/10.3390/cancers17183077
Primary Topic
Chromatin Remodeling and Cancer
Type
article
Field-Weighted Citation Impact
0.00
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article

Clinical and Molecular Characteristics of 100 Atypical Teratoid Rhabdoid Tumor Patients from Low- and Middle-Income Countries

Amal Mosaab, Mohamed El-Beltagy, Hanafy Hafez, Alaa Elhaddad et al.
Cancers
Chromatin Remodeling and Cancer
article

Clinical and Molecular Characteristics of 100 Atypical Teratoid Rhabdoid Tumor Patients from Low- and Middle-Income Countries

Amal Mosaab, Mohamed El-Beltagy, Hanafy Hafez, Alaa Elhaddad, Ahmed Elhemaly, Eslam Maher, Mohamed S. Zaghloul, Shaimaa Aboubakr, Mark W. Kieran, Shahenda El‐Naggar, Volker Hovestadt, Amal Refaat, N Ismail, Dina Yassin, Hala Taha, Omar Ahmed, Abdelrahman Enayat
article en

Abstract

In this cohort, no significant survival differences were observed among the methylation subgroups. The higher treatment-related mortality in our cohort compared to the original protocol's toxic-related deaths suggested that intensive and lengthy chemotherapy regimens may need modification for our population. The need for a short intensified approach, including a limited induction cycle followed by an intensified high-dose consolidation therapy, may be more appropriate for our patients with low socioeconomic status to avoid a repeated and prolonged course of protracted neutropenia.

CancersVol. 17(18)
Boston Children's Hospital (US), Cairo University (EG), King Hussein Cancer Center (JO), Hopp Children's Cancer Center Heidelberg (DE), Dana-Farber Cancer Institute (US), National Water Research Center (EG), Boston Children's Museum (US), Children Cancer Hospital (EG), Imperial College London (GB)
Openalex Percentile: Top 77%
Chromatin Remodeling and Cancer
DOIOpen Access PDFOpenAlex
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Clinical and Molecular Characteristics of 100 Atypical Teratoid Rhabdoid Tumor Patients from Low- and Middle-Income Countries — Amal Mosaab, Mohamed El-Beltagy, et al. · Cancers (2025) | TGRS Research Map | TGRS