Study of the metabolism of unesterified fatty acids and ketone bodies against the background of acute hypoxia of different genesis and loading with antihypoxants

Hypoxia is a frequent cause of hypoenergetic states, in which lipid hydrolysis increases, fatty acid synthesis increases, which leads to an increase in their concentration, as well as the concentration of ketone bodies, which are substrates of oxidation in tissues. The multiplicity of pathological changes in the body under hypoxia requires the search for effective antihypoxants, as which can be used extracts of black currant and medicinal raspberry. The aim of the work was to study the peculiarities of metabolism of unesterified fatty acids and ketone bodies during antihypoxant loading on the background of acute hemic, histotoxic and hypoxic normobaric hypoxia. The study was carried out on white rats. During 15 days the animals received intragastrically extracts of black currant, raspberry medicinal, a mixture of these extracts in the ratio 1:1 and cytochrome C, which was administered intramuscularly. The concentration of nonesterified fatty acids (NEFA) was determined in serum, heart and brain tissues of rats, and ketone bodies — in serum. The increase in the concentrations of FAFAs and ketone bodies in all tissues under acute hypoxia of various genesis is an indicator of lipid metabolism disorders and failure of adaptation mechanisms. The introduction of antihypoxants contributed to the decrease in the concentration of fatty acids and ketone bodies in the tissues of rats, which indicates that the studied preparations have a high lipidoprotective and antioxidant effect, and the highest efficiency is demonstrated by a mixture of extracts of medicinal raspberry and black currant in the ratio of 1:1.