Genetic Variants in Cytokines IL-10 and IL-17A Are Associated with the Risk and Severity of Sporadic Parkinson’s Disease in Mexican Patients
<i>IL-17A</i>_rs8193036 was found to be associated with increased PD risk (<i>p</i> < 0.010, OR = 1.91, CI<sub>95%</sub> = 1.22-2.98). The genetic variants <i>IL-10</i>_rs1800896, <i>IL-10</i>_rs1800872, and <i>IL_17A</i>_rs8193036 were related to the inflammatory process in sporadic MM PD patients, suggesting that they may play potential roles in the development and severity of the disease.
Authors
- Marisol López (ORCID: https://orcid.org/0000-0002-3954-8052)
- Alberto Ortega‐Vázquez (ORCID: https://orcid.org/0000-0003-2803-9444)
- Nancy Monroy‐Jaramillo (ORCID: https://orcid.org/0000-0003-2611-0972)
- Laura Adalid‐Peralta (ORCID: https://orcid.org/0000-0002-1010-698X)
Institutions
- Universidad Autónoma Metropolitana (MX)
- Instituto Nacional de Neurología y Neurocirugía (MX)
Publication Details
- Journal
- Life
- Published
- 2025-09-20
- DOI
- https://doi.org/10.3390/life15091480
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00