Random Forest Adaptation for High-Dimensional Count Regression

The analysis of high-dimensional count data presents a unique set of challenges, including overdispersion, zero-inflation, and complex nonlinear relationships that traditional generalized linear models and standard machine learning approaches often fail to adequately address. This study introduces and validates a novel Random Forest framework specifically developed for high-dimensional Poisson and Negative Binomial regression, designed to overcome the limitations of existing methods. Through comprehensive simulations and a real-world genomic application to the Norwegian Mother and Child Cohort Study, we demonstrate that the proposed methods achieve superior predictive accuracy, quantified by lower root mean squared error and deviance, and critically produced exceptionally stable and interpretable feature selections. Our theoretical and empirical results show that these distribution-optimized ensembles significantly outperform both penalized-likelihood techniques and naive-transformation-based ensembles in balancing statistical robustness with biological interpretability. The study concludes that the proposed frameworks provide a crucial methodological advancement, offering a powerful and reliable tool for extracting meaningful insights from complex count data in fields ranging from genomics to public health.