Comparative Efficacy and Safety of Anakinra and Canakinumab in Patients With <scp>VEXAS</scp> Syndrome: An International Multicenter Study
Canakinumab demonstrated superior clinical response and drug survival with fewer adverse events compared with anakinra. Monthly canakinumab 300 mg may be considered as an effective steroid-sparing therapeutic option for patients with VEXAS.
Authors
- Maël Heiblig (ORCID: https://orcid.org/0000-0003-1682-8657)
- Sophie Georgin‐Lavialle (ORCID: https://orcid.org/0000-0001-6668-8854)
- Aurore Meyer
- Michael Zisapel
- Olivier Kosmider (ORCID: https://orcid.org/0000-0002-6021-4057)
- Maxime Samson (ORCID: https://orcid.org/0000-0002-6547-232X)
- Shaye Kivity (ORCID: https://orcid.org/0000-0002-8391-5446)
- Iftach Sagy (ORCID: https://orcid.org/0000-0002-2720-9934)
- Elisa Diral (ORCID: https://orcid.org/0000-0002-4994-7719)
- Jérôme Hadjadj (ORCID: https://orcid.org/0000-0002-2520-3272)
- Lorenzo Dagna (ORCID: https://orcid.org/0000-0002-7428-315X)
- Alessandro Tomelleri (ORCID: https://orcid.org/0000-0002-5440-2078)
- François Lifermann
- Corrado Campochiaro (ORCID: https://orcid.org/0000-0001-6806-3794)
- O. Fain (ORCID: https://orcid.org/0000-0002-1974-3870)
- Alice Garnier
- Samuel Ardois (ORCID: https://orcid.org/0009-0009-9631-4445)
- Hagit Peleg
- David Ozeri
- Karim Sacré (ORCID: https://orcid.org/0000-0002-6544-234X)
- Valentin Lacombe (ORCID: https://orcid.org/0000-0002-7184-752X)
- Vincent Grobost (ORCID: https://orcid.org/0009-0003-5352-7949)
- Thibault Comont (ORCID: https://orcid.org/0000-0002-6891-9238)
- Oshrat E Tayer-Shifman (ORCID: https://orcid.org/0009-0008-3571-7243)
- A. Maria (ORCID: https://orcid.org/0000-0002-0868-5804)
- Vincent Jachiet (ORCID: https://orcid.org/0000-0002-1163-9796)
- Dafne Capelusnik (ORCID: https://orcid.org/0000-0001-9336-0416)
- Estibaliz Lazaro (ORCID: https://orcid.org/0000-0002-4206-7399)
- Tali Eviatar (ORCID: https://orcid.org/0000-0002-2894-4033)
- Jean‐David Bouaziz (ORCID: https://orcid.org/0000-0002-4993-2461)
- Laurent Arnaud (ORCID: https://orcid.org/0000-0002-8077-8394)
- A. Mékinian (ORCID: https://orcid.org/0000-0003-2849-3049)
- Benjamin Terrier (ORCID: https://orcid.org/0000-0001-6612-7336)
- Ori Elkayam (ORCID: https://orcid.org/0000-0002-1873-8930)
- Pascal Woaye‐Hune
- A. Cantagrel
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Centre National de la Recherche Scientifique (FR)
- Université Toulouse III - Paul Sabatier (FR)
- Vita-Salute San Raffaele University (IT)
- Inserm (FR)
- Tel Aviv University (IL)
- Université de Montpellier (FR)
- Université Paris Cité (FR)
- Tel Aviv Sourasky Medical Center (IL)
- Sheba Medical Center (IL)
- Hadassah Medical Center (IL)
- Soroka Medical Center (IL)
- Meir Medical Center (IL)
- San Raffaele University of Rome (IT)
- Centre Hospitalier Universitaire de Bordeaux (FR)
- Centre Hospitalier Universitaire de Nantes (FR)
- Centre Hospitalier Universitaire de Toulouse (FR)
- Maastricht University (NL)
- Sorbonne Université (FR)
- Hôpital Cochin (FR)
- Centre Hospitalier Universitaire de Montpellier (FR)
- Services déconcentrés d'appui à la recherche Nouvelle-Aquitaine-Bordeaux (FR)
- Institut universitaire du cancer de Toulouse Oncopole (FR)
- Hospices Civils de Lyon (FR)
- Hôpital Saint-Antoine (FR)
- Laboratoire de Thermique et Energie de Nantes (FR)
- Centre Hospitalier Universitaire d'Angers (FR)
- Hôpital Lyon Sud (FR)
- Department of Health (TW)
- CHU Dijon Bourgogne (FR)
- Université Bourgogne Franche-Comté (FR)
- Centre Hospitalier Universitaire de Clermont-Ferrand (FR)
- Centre de Recherche Saint-Antoine (FR)
- Centre Hospitalier d'Albi (FR)
- Institut Cochin (FR)
- Centre Hospitalier de Dax –Côte d’Argent (FR)
- Hôpital Saint-Louis (FR)
- Hôpital Bichat-Claude-Bernard (FR)
- Hôpitaux Universitaires de Strasbourg (FR)
- Centre Hospitalier Départemental Vendée (FR)
- Hôpital Paule de Viguier (FR)
- Centre Hospitalier Universitaire de Rennes (FR)
- Hôpital Tenon (FR)
- Nantes Université (FR)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2025-09-22
- DOI
- https://doi.org/10.1002/art.43384
- Citations
- 5
- Primary Topic
- Otitis Media and Relapsing Polychondritis
- Type
- article
- Field-Weighted Citation Impact
- 8.34
Funders
- Amgen
- Eli Lilly and Company
- Pfizer
- AstraZeneca
- Biogen
- Alexion Pharmaceuticals
- Celgene
- Jazz Pharmaceuticals
- Argenx
- Servier
- Swedish Orphan Biovitrum
- Medac
- Grifols
- Chugai Pharmaceutical
- Cilag