Therapeutic Effects of Stem Cells from Human Exfoliated Deciduous Teeth and Their Conditioned Medium in Cisplatin-Induced Acute Kidney Injury: An In Vivo Study
SHED-CM demonstrated superior therapeutic efficacy over SHED injection in mitigating cisplatin-induced AKI, likely due to extracellular vesicle-mediated paracrine effects. These findings support SHED-CM as a promising, non-invasive alternative for MSC-EV-based AKI therapy.
Authors
- Sareh Soroushzadeh (ORCID: https://orcid.org/0000-0003-3953-4651)
- Nosrat Nourbakhsh (ORCID: https://orcid.org/0000-0002-0607-7362)
- Hooman Mohammad Talebi (ORCID: https://orcid.org/0000-0001-5530-0826)
- Ardeshir Talebi (ORCID: https://orcid.org/0000-0001-7313-5086)
- Seyed Ali Mosaddad (ORCID: https://orcid.org/0000-0001-6963-8289)
- Miguel Gómez‐Polo (ORCID: https://orcid.org/0000-0001-8614-8484)
- Sahar Talebi
- Sara Nikpoor
Institutions
- Isfahan University of Medical Sciences (IR)
- Universidad Complutense de Madrid (ES)
- Academic Center for Education, Culture and Research (IR)
- Islamic Azad University of Falavarjan (IR)
- Isfahan Fertility and Infertility Center (IR)
- Saveetha University (IN)
Publication Details
- Journal
- Biology
- Published
- 2025-09-22
- DOI
- https://doi.org/10.3390/biology14091305
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 0.00