Humoral response induced after intranasal vaccination with heat inactivated Acinetobacter baumannii protects immunodeficient mice against hypervirulent LAC-4 strain
Overall, our results demonstrate that administration of HK bacteria can induce protective immunity against <i>A. baumannii</i> in both immuno-competent and immuno-compromised mice and that these HK bacteria can activate the human adaptive immune system.
Authors
- Fabienne Andris (ORCID: https://orcid.org/0000-0002-8644-1020)
- Xavier De Bolle (ORCID: https://orcid.org/0000-0002-3845-3043)
- Éric Muraille (ORCID: https://orcid.org/0000-0003-1250-5228)
- Lorenzo Bossi
- Yohannes Tafesse (ORCID: https://orcid.org/0000-0003-3883-6244)
- Sébastien Denanglaire (ORCID: https://orcid.org/0000-0001-7985-716X)
- Véronique Flamand (ORCID: https://orcid.org/0000-0002-8906-3758)
- Sandrine Delbauve
- David Vermijlen (ORCID: https://orcid.org/0000-0002-7605-8845)
- Emeline Barbieux (ORCID: https://orcid.org/0000-0002-3263-0264)
- Charles Van der Henst (ORCID: https://orcid.org/0000-0002-3451-9439)
- Katy Poncin (ORCID: https://orcid.org/0000-0003-4197-6459)
- Juliette Van Buylaere
- Thomas Rouma
Institutions
- Université Libre de Bruxelles (BE)
- Vrije Universiteit Brussel (BE)
- University of Namur (BE)
- American Pharmacists Association (US)
- Institute of Pathology and Genetics (BE)
- Clinical Research Solutions (US)
- VIB-VUB Center for Structural Biology (BE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-22
- DOI
- https://doi.org/10.3389/fimmu.2025.1641997
- Citations
- 1
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.59
Funders
- European Commission
- Fonds De La Recherche Scientifique - FNRS
- Vlaams Instituut voor Biotechnologie
- Vlaamse regering
- HORIZON EUROPE Framework Programme
- Fonds pour la Formation à la Recherche dans l’Industrie et dans l’Agriculture