Associations between relative abundances of Bifidobacterium species in the gut and DNA methylation of cortisol-related genes in a pediatric population
These findings suggest that microbiome-derived metabolites, such as folate, may modulate DNA methylation and stress physiology. This work provides new insights for exploring how the gut microbiome impacts mental health and stress resilience, offering potential pathways for microbiome-targeted interventions.
Authors
- Daphne Koinis‐Mitchell (ORCID: https://orcid.org/0000-0002-5009-1647)
- Viren A. D’Sa (ORCID: https://orcid.org/0000-0002-3476-8419)
- Shelley McCann (ORCID: https://orcid.org/0000-0002-9753-7968)
- Vanja Klepac‐Ceraj (ORCID: https://orcid.org/0000-0001-5387-5706)
- Candace R. Lewis
- Kevin S. Bonham (ORCID: https://orcid.org/0000-0003-3200-7533)
- Alexandra Volpe
- Qiyun Zhu (ORCID: https://orcid.org/0000-0002-3568-6271)
- Sean Deoni (ORCID: https://orcid.org/0000-0002-0633-6328)
- Samantha A. Harker (ORCID: https://orcid.org/0009-0002-1271-3924)
Institutions
- Translational Genomics Research Institute (US)
- Gates Foundation (US)
- Wellesley College (US)
- Brown University (US)
- Arizona State University (US)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-09-22
- DOI
- https://doi.org/10.3389/fmicb.2025.1558809
- Citations
- 1
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Northwestern University
- Johns Hopkins University
- Johns Hopkins Bloomberg School of Public Health
- Duke Clinical Research Institute