DeepFocusNet: An Attention-Augmented Deep Neural Framework for Robust Colorectal Cancer Classification in Whole-Slide Histology Images

A major cause of cancer-related mortality globally is colorectal cancer, which emphasises the critical need for state-of-the-art diagnostic tools for early identification and categorisation. We use deep learning methodology to classify colorectal cancer histology images into eight different categories automatically. To improve classification accuracy and maximise feature extraction, we create a DeepFocusNet architecture with attention approaches using a dataset of 5000 high-resolution (150 × 150) histological images. To improve model generalisation, we combine data augmentation, fine-tuning, and freezing early layers into our progressive training approach. Additionally, we create full-scale images using heatmaps and multi-class overlays after breaking up large-scale histology images (5000 × 5000) into smaller windows for classification using a special tiling technique. Attention mechanisms are added to improve the model’s performance and interpretability, as they are proven to focus on the most important histopathological traits. The model provides pathologists with high-resolution probability maps that aid in precise and speedy patient identification. The robustness of our methodology is demonstrated by empirical findings, opening the door for clinical applications of AI-driven histopathological investigation. Pathologists can receive precise and efficient diagnostic support from the final system thanks to its high-resolution probability maps and 97% classification accuracy. Empirical results provide evidence of our methodology’s robustness and show its potential for real-world clinical applications in AI-assisted histopathology.