Palladium-Catalyzed Asymmetric Carbonylation of Alkynes to Axially Chiral Carbothioate Esters
Herein, we report a novel palladium-catalyzed asymmetric hydrothioesterification of alkynes under mild conditions, enabling the precise construction of axially chiral carboxylic thioester derivatives with excellent yields, regioselectivity, <i>E</i>/<i>Z</i> selectivity, and enantioselectivity. Disulfides and thiosulfonates were applicable, as well.
Authors
- Xiao‐Feng Wu (ORCID: https://orcid.org/0000-0001-6622-3328)
- Yang Yuan (ORCID: https://orcid.org/0000-0001-8526-4483)
- Ting Yang (ORCID: https://orcid.org/0000-0002-4131-1302)
- Yong‐Gui Zhou (ORCID: https://orcid.org/0000-0002-3321-5521)
- Yao Wang (ORCID: https://orcid.org/0000-0002-6589-8021)
Institutions
- Dalian Institute of Chemical Physics (CN)
- Chinese Academy of Sciences (CN)
- Leibniz Institute for Catalysis (DE)
- Dalian National Laboratory for Clean Energy (CN)
Publication Details
- Journal
- Journal of the American Chemical Society
- Published
- 2025-09-22
- DOI
- https://doi.org/10.1021/jacs.5c11864
- Citations
- 9
- Primary Topic
- Axial and Atropisomeric Chirality Synthesis
- Type
- article
- Field-Weighted Citation Impact
- 8.42