[ <sup>18</sup> F]Tetrafluoroborate PET/CT for detecting differentiated thyroid cancer: phase-II study protocol
This prospective, multicenter phase-2 clinical trial includes adult patients with DTC and pathologically confirmed cervical lymph node metastases scheduled for thyroidectomy and lymph node dissection (Group 1) and patients with recurrent or persistent DTC scheduled for radioiodine therapy (Group 2). [<sup>18</sup>F]TFB PET/CT will be compared to current imaging modalities and post-therapy scintigraphy. Primary outcomes include optimal imaging time points, sensitivity, specificity, SUV<sub>max</sub>, and TBR<sub>max</sub> for lymph node metastases and suspected lesions. Secondary outcomes involve [<sup>18</sup>F]TFB kinetics, NIS expression correlation, and safety profiles. In conclusion, [<sup>18</sup>F]TFB PET/CT holds the potential for enhancing pre-operative lymph node metastasis detection and predicting [<sup>131</sup>I] therapy response, potentially improving surgical and therapeutic outcomes for DTC patients.
Authors
- Albert D. Windhorst (ORCID: https://orcid.org/0000-0002-1250-7656)
- Bart de Keizer (ORCID: https://orcid.org/0000-0002-6270-9483)
- Menno R. Vriens (ORCID: https://orcid.org/0000-0003-0521-1125)
- Tessa M. van Ginhoven (ORCID: https://orcid.org/0000-0002-9365-4892)
- W. Edward Visser (ORCID: https://orcid.org/0000-0002-5248-863X)
- Frederik A. Verburg (ORCID: https://orcid.org/0000-0002-7161-0979)
- Hannelore I. Coerts
- Mark J C van Treijen (ORCID: https://orcid.org/0000-0003-3853-297X)
Institutions
- University Medical Center Utrecht (NL)
- Erasmus MC Cancer Institute (NL)
- Amsterdam University Medical Centers (NL)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Future Oncology
- Published
- 2025-09-22
- DOI
- https://doi.org/10.1080/14796694.2025.2560294
- Primary Topic
- Thyroid Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- KWF Kankerbestrijding