Investigating causal effects of HDL-C on cognitive function through cross-sectional and Mendelian randomization analyses: concentration–response patterns and clues for Alzheimer’s disease prevention
Our findings suggest that maintaining optimal serum HDL-C levels may help preserve cognitive function in older adults. Notably, sex-specific associations were observed, warranting further investigation into underlying mechanisms.
Authors
- Zheyu Zhang (ORCID: https://orcid.org/0000-0003-1907-0765)
- Haitao Jiang (ORCID: https://orcid.org/0000-0001-7081-4059)
- Longmin Fan
Institutions
- Central South University (CN)
- Second Xiangya Hospital of Central South University (CN)
Publication Details
- Journal
- BioData Mining
- Published
- 2025-09-22
- DOI
- https://doi.org/10.1186/s13040-025-00484-3
- Primary Topic
- Cholesterol and Lipid Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00