Identification of key symptoms for a Core Outcome Set for research in vulvar lichen sclerosus: a CORALS symptom domain initiative

This study identified five key symptoms for evaluating vulvar LS. Although designed to capture symptoms from all patients with LS, the survey and scoping review both included small populations of male and paediatric participants, highlighting the need for further research in these populations. Based on the results, we suggest measurement of itch, pain, skin cuts and tears, burning and (when relevant) pain with sex within the symptoms core outcome domain for vulvar LS. These findings will be used to inform content validity studies when evaluating potential measurement instruments for the Core Outcome Set.