Mesenteric Ischemia and Bacterial Translocation Precipitate the Intoxication Phase of Yellow Fever
Our findings tie together several recent and historically unexplained observations surrounding the highly lethal intoxication phase of YF in humans: a high aspartate aminotransferase/alanine aminotransferase ratio, "black vomit," pancreatitis, and paradoxical neutrophilia. A better appreciation for the drivers of mesenteric ischemia, and preemption of bacterial sepsis, may improve outcomes in cases of severe YF.
Authors
- Xueer Qiu
- Mark Sharobim
- Chung-Chou H. Chang (ORCID: https://orcid.org/0000-0001-8719-2508)
- Amaro Nunes Duarte‐Neto (ORCID: https://orcid.org/0000-0001-6659-7186)
- Mateus Vailant Thomazella (ORCID: https://orcid.org/0000-0002-1527-6910)
- Esper Georges Kallas (ORCID: https://orcid.org/0000-0003-2026-6925)
- Cássia Gisele Terrassani Silveira (ORCID: https://orcid.org/0000-0002-0932-7769)
- Carolina Argondizo Correia (ORCID: https://orcid.org/0000-0003-4526-0896)
- Eduard Matkovic (ORCID: https://orcid.org/0000-0003-1492-5170)
- Mariana Prado Marmorato (ORCID: https://orcid.org/0000-0002-0644-0862)
- Marisa Dolhnikoff (ORCID: https://orcid.org/0000-0002-9073-9989)
- Adam L. Bailey (ORCID: https://orcid.org/0000-0002-6560-9680)
- Erik Sanson
- Andrew P. Norton (ORCID: https://orcid.org/0000-0001-8297-6100)
Institutions
- University of Wisconsin System (US)
- University of Wisconsin–Madison (US)
- Universidade de São Paulo (BR)
- Instituto Butantan (BR)
- Wisconsin Division of Public Health (US)
- Hospital for Tropical Diseases (VN)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-09-19
- DOI
- https://doi.org/10.1093/infdis/jiaf483
- Primary Topic
- Vibrio bacteria research studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00