Association of Umbilical Cord Blood Serotonin Levels with Neurodevelopmental Outcomes
To our knowledge, this study is the first to evaluate the relationship between placental 5-HT levels and cord blood 5-HT levels at birth. The lack of association suggests that cord blood 5-HT levels are likely to be a better index of fetal 5-HT exposure. Associations between cord blood 5-HT and child cognitive development are consistent with previous studies showing an association between maternal 5-HT levels and neurodevelopmental trajectories. Further research is needed to better characterize these relationships and to elucidate the distinct contributions of maternal, placental, and fetal 5-HT sources across developmental time points.
Authors
- Morgan R. Firestein (ORCID: https://orcid.org/0000-0002-3814-8700)
- Hannah Yueh
- Lauren C. Shuffrey (ORCID: https://orcid.org/0000-0003-3631-5971)
- Jeremy Veenstra‐VanderWeele (ORCID: https://orcid.org/0000-0002-6349-1076)
- William P. Fifer (ORCID: https://orcid.org/0000-0002-6936-9303)
- George Anderson (ORCID: https://orcid.org/0000-0001-7243-0817)
- Hein J. Odendaal (ORCID: https://orcid.org/0000-0001-5672-2000)
- Amy Elliott (ORCID: https://orcid.org/0000-0003-0608-8931)
- Rebecca N. Siegel
- Kally C O’Reilly Sparks (ORCID: https://orcid.org/0000-0002-2998-9209)
Institutions
- Stellenbosch University (ZA)
- Avera Health (US)
- Yale University (US)
- New York Psychoanalytic Society and Institute (US)
- New York State Psychiatric Institute
- New York University (US)
- Columbia University (US)
Publication Details
- Journal
- Developmental Neuroscience
- Published
- 2025-09-22
- DOI
- https://doi.org/10.1159/000547803
- Citations
- 1
- Primary Topic
- Prenatal Substance Exposure Effects
- Type
- article
- Field-Weighted Citation Impact
- 3.49