Age-associated B cells enhance tertiary lymphoid structures in the liver and promote HCC formation
These findings demonstrate that ABCs promote TLS formation and growth, facilitating B-cell recruitment to the liver and supporting HCC progression. Targeting T-bet-dependent ABC differentiation may represent a novel strategy to limit TLS formation and slow HCC progression.
Authors
- Mads Kjølby (ORCID: https://orcid.org/0000-0002-1043-6137)
- Sven Clausen (ORCID: https://orcid.org/0000-0003-0224-348X)
- Peter Breining (ORCID: https://orcid.org/0000-0001-6127-5065)
- Mathilde S. Blaavand (ORCID: https://orcid.org/0009-0009-5824-7157)
- Martin Kristian Thomsen (ORCID: https://orcid.org/0000-0002-5055-7531)
- Kenneth Green (ORCID: https://orcid.org/0000-0001-7798-4763)
- Mikkel Holm Vendelbo (ORCID: https://orcid.org/0000-0003-0431-2522)
- Søren E. Degn (ORCID: https://orcid.org/0000-0001-5409-045X)
- Lisbeth Jensen (ORCID: https://orcid.org/0000-0003-4702-8222)
- A. Morsing
- Camilla R. Benjaminsen
- Julia K. Demtröder
- Johannes Skraep
Institutions
- Aarhus University (DK)
- Aarhus University Hospital (DK)
Publication Details
- Journal
- Hepatology Communications
- Published
- 2025-09-22
- DOI
- https://doi.org/10.1097/hc9.0000000000000816
- Citations
- 4
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 3.19