Targeting hepatocyte-specific SLC2A8 blocks hepatic steatosis and dissociates TCA cycle flux inhibition from glutamine anaplerosis
Deleting the hepatocyte carbohydrate transporter GLUT8 suppresses TCA cycle flux without inducing compensatory glutamine anaplerosis. The net effect of this is liver protection against multiple forms of dietary insult. Given that selective pharmacological GLUT8 inhibition is feasible, GLUT8 may be a viable target to abate metabolic dysfunction-associated steatohepatitis and other complications of obesity.
Authors
- Joshua A. Adams (ORCID: https://orcid.org/0009-0006-4589-859X)
- Andrew Tilston-Lünel (ORCID: https://orcid.org/0000-0002-5582-6884)
- Samuel Ballentine (ORCID: https://orcid.org/0000-0002-6339-548X)
- Yiming Zhang (ORCID: https://orcid.org/0000-0002-6020-0237)
- Jiameng Sun (ORCID: https://orcid.org/0000-0002-1176-8010)
- Eric Tycksen (ORCID: https://orcid.org/0000-0001-6362-0141)
- Paul W. Hruz (ORCID: https://orcid.org/0000-0002-1478-3355)
- Roland E. Dolle (ORCID: https://orcid.org/0000-0001-5574-6019)
- Cassandra B. Higgins (ORCID: https://orcid.org/0000-0003-4751-9611)
- Brian J. DeBosch (ORCID: https://orcid.org/0000-0002-9924-7921)
- Monique R. Heitmeier
Institutions
- Washington University in St. Louis (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Hepatology Communications
- Published
- 2025-09-22
- DOI
- https://doi.org/10.1097/hc9.0000000000000810
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00