Examining the effects of varenicline and naltrexone on delay discounting among individuals with alcohol use disorder
These findings suggest that naltrexone may reduce delay discounting in individuals with AUD, but primarily among those with lower discounting rates. The results highlight the importance of baseline traits in understanding medication effects on decision-making. Given the small sample size, future research should replicate these findings in larger trials and explore whether delay discounting could serve as a biomarker for personalized AUD treatment.
Authors
- Annabel Kady (ORCID: https://orcid.org/0000-0003-1884-5856)
- Steven J. Nieto (ORCID: https://orcid.org/0000-0003-1158-5211)
- Lara A. Ray
- Wave‐Ananda Baskerville (ORCID: https://orcid.org/0000-0003-0198-039X)
- James M. MacKillop (ORCID: https://orcid.org/0000-0002-8695-1071)
- Alicia Izquierdo (ORCID: https://orcid.org/0000-0001-9897-2091)
Institutions
- University of California, Los Angeles (US)
- Wayne State University (US)
- Neurobehavioral Systems (US)
Publication Details
- Journal
- Alcohol and Alcoholism
- Published
- 2025-09-16
- DOI
- https://doi.org/10.1093/alcalc/agaf060
- Primary Topic
- Decision-Making and Behavioral Economics
- Type
- article
- Field-Weighted Citation Impact
- 0.00